1: 46 percent / pyridine / 16 h / 0 °C 2: 66 percent / Li2CuCl4 / tetrahydrofuran / 12 h / 20 °C 3: 98 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - -50 °C 4: 92 percent / p-TsOH / methanol / 16 h / 20 °C 5: 88 percent / Na(Hg); Na2HPO4 / methanol / 21 h / 20 °C 6: 91 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme

1.1: 46 percent / pyridine / 16 h / 0 °C 2.1: 66 percent / Li2CuCl4 / tetrahydrofuran / 12 h / 20 °C 3.1: CuI / 16 h / 60 °C 3.2: Me2Cu(CN)(MgCl)2; DMPU / tetrahydrofuran / -78 - 0 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11323436', constants.ctx, '0')">aluminum oxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=20&deg;C;&nbsp;20&nbsp;h;&nbsp;<br /> &nbsp;