(2E,4E)-6-(4-甲氧基苯基)-N-(2-甲基丙基)-2,4-己二烯酰胺合成路线 （共 16 条）
反应条件
1: CuI / (Ph3P)2PdCl2 / triethylamine
2: 1.) H2; 2.) NEt3 / 1.) Pd/C / 1.) EtOAc; 2.) DMSO, CH2Cl2
3: piperidine / acetonitrile
4: DMAP / pyridine
5: 73 percent / bis-trimethylsilylacetamide / Mo(CO)6 / toluene
6: 1.) aq. HCl; 2.) phenyl N-phenylphosphoramidochloridate, NEt3 / 1.) dioxane; 2.) CH2Cl2
View Scheme
参考文献
Blade, Robert J.; Robinson, J. Edward
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3209 - 3210
反应条件
1: 1.) H2; 2.) NEt3 / 1.) Pd/C / 1.) EtOAc; 2.) DMSO, CH2Cl2
2: piperidine / acetonitrile
3: DMAP / pyridine
4: 73 percent / bis-trimethylsilylacetamide / Mo(CO)6 / toluene
5: 1.) aq. HCl; 2.) phenyl N-phenylphosphoramidochloridate, NEt3 / 1.) dioxane; 2.) CH2Cl2
View Scheme
参考文献
Blade, Robert J.; Robinson, J. Edward
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3209 - 3210
反应条件
1: piperidine / acetonitrile
2: DMAP / pyridine
3: 73 percent / bis-trimethylsilylacetamide / Mo(CO)6 / toluene
4: 1.) aq. HCl; 2.) phenyl N-phenylphosphoramidochloridate, NEt3 / 1.) dioxane; 2.) CH2Cl2
View Scheme
参考文献
Blade, Robert J.; Robinson, J. Edward
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3209 - 3210
反应条件
1: DMAP / pyridine
2: 73 percent / bis-trimethylsilylacetamide / Mo(CO)6 / toluene
3: 1.) aq. HCl; 2.) phenyl N-phenylphosphoramidochloridate, NEt3 / 1.) dioxane; 2.) CH2Cl2
View Scheme
参考文献
Blade, Robert J.; Robinson, J. Edward
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3209 - 3210
反应条件
2: (i) nBuLi, (ii) /BRN= 1721203/, (iii) I2, (irradiation)
3: aq. HCl / dioxane
4: (i) (COCl)2, (ii) /BRN= 385626/
View Scheme
参考文献
Price,S.J.; Pinder,A.R.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2568 - 2571
反应条件
1: PBr5
3: (i) nBuLi, (ii) /BRN= 1721203/, (iii) I2, (irradiation)
4: aq. HCl / dioxane
5: (i) (COCl)2, (ii) /BRN= 385626/
View Scheme
参考文献
Price,S.J.; Pinder,A.R.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2568 - 2571
反应条件
1: LiAlH4
2: PBr5
4: (i) nBuLi, (ii) /BRN= 1721203/, (iii) I2, (irradiation)
5: aq. HCl / dioxane
6: (i) (COCl)2, (ii) /BRN= 385626/
View Scheme
参考文献
Price,S.J.; Pinder,A.R.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2568 - 2571
反应条件
1: (i) nBuLi, (ii) /BRN= 1721203/, (iii) I2, (irradiation)
2: aq. HCl / dioxane
3: (i) (COCl)2, (ii) /BRN= 385626/
View Scheme
参考文献
Price,S.J.; Pinder,A.R.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2568 - 2571
反应条件
Schwartz's reagent; Pd(PPh3)2
Yield given. Multistep reaction;
参考文献
Crombie, Leslie; Horsham, Mark A.; Blade, Robert J.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4879 - 4882
反应条件
2: 1.) Cp2ZrCl(H) / 2.) (Ph3P)2Pd(O)
View Scheme
参考文献
Crombie, Leslie; Horsham, Mark A.; Blade, Robert J.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4879 - 4882
