(2E,4E)-6-(4-甲氧基苯基)-N-(2-甲基丙基)-2,4-己二烯酰胺合成路线 （共 16 条）
反应条件
1: n-butyl lithium
2: 1.) Cp2ZrCl(H) / 2.) (Ph3P)2Pd(O)
View Scheme
参考文献
Crombie, Leslie; Horsham, Mark A.; Blade, Robert J.
Tetrahedron Letters, 1987 , vol. 28, # 41 p. 4879 - 4882
反应条件
1: 87 percent / KF*2H2O / dimethylformamide / 5 h / Ambient temperature
2: 1.) DIBAH, 2.) Pd(PPh3)4 / 1.) hexane, 55 deg C 7 h, 2.) THF, reflux,1 h
3: 20percent HCl / dioxane / 12 h / 100 °C
4: 1.) phenyl N-phenylphosphoramidochloridate, Et3N / 1.) CH2Cl2, 15 min, 2.) RT, 5 h
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Lippolis, Vito; Benetti, Massimo
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 783 - 791
反应条件
1: 87 percent / CuBr / tetrahydrofuran / 2 h / 65 °C
2: 87 percent / KF*2H2O / dimethylformamide / 5 h / Ambient temperature
3: 1.) DIBAH, 2.) Pd(PPh3)4 / 1.) hexane, 55 deg C 7 h, 2.) THF, reflux,1 h
4: 20percent HCl / dioxane / 12 h / 100 °C
5: 1.) phenyl N-phenylphosphoramidochloridate, Et3N / 1.) CH2Cl2, 15 min, 2.) RT, 5 h
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Lippolis, Vito; Benetti, Massimo
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 783 - 791
反应条件
1: 1.) DIBAH, 2.) Pd(PPh3)4 / 1.) hexane, 55 deg C 7 h, 2.) THF, reflux,1 h
2: 20percent HCl / dioxane / 12 h / 100 °C
3: 1.) phenyl N-phenylphosphoramidochloridate, Et3N / 1.) CH2Cl2, 15 min, 2.) RT, 5 h
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Lippolis, Vito; Benetti, Massimo
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 783 - 791
反应条件
(i) (COCl)2, (ii) /BRN= 385626/; Multistep reaction;
参考文献
Price,S.J.; Pinder,A.R.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2568 - 2571
反应条件
hydrogenchloride; triethylamine; phenyl N-phenylphosphoroamidochloridate
1.) dioxane; 2.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Blade, Robert J.; Robinson, J. Edward
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3209 - 3210
