噻吩并[3,2-b]噻吩合成路线 （共 55 条）
反应条件
trichlorophosphate in 1,2-dichloro-ethane T=0°C; Reflux;
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; THE UNIVERSITY OF MELBOURNE; MONASH UNIVERSITY; SECURENCY INTERNATIONAL PTY LTD; EVANS, Richard; GUPTA, Akhil; ALI, Abdelselam Saeed
Patent: WO2011/137487 A1, 2011 ;
Location in patent: Page/Page column 31 ;
反应条件
1: thieno[3,2-b]thiophene With n-butyllithium in tetrahydrofuran T=0°C; 0.5 h; Inert atmosphere; 2: N-methyl-N-formyl-aniline in tetrahydrofuran T=20°C; 2 h; Inert atmosphere;
参考文献
Ito, Hiroki; Yamamoto, Tatsuya; Yoshimoto, Noriyuki; Tsushima, Noboru; Muraoka, Hiroki; Ogawa, Satoshi
Heteroatom Chemistry, 2013 , vol. 24, # 1 p. 25 - 35
反应条件
1: thieno[3,2-b]thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; Inert atmosphere; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere;
参考文献
Huang, Peng-Yi; Kim, Choongik; Chen, Ming-Chou
Synlett, 2011 , # 15 art. no. W10711ST, p. 2151 - 2156
反应条件
bromine in carbon disulfide 23 h; Heating;
参考文献
Yui, Koji; Ishida, Hideki; Aso, Yoshio; Otsubo, Tetsuo; Ogura, Fumio; et al.
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 5 p. 1547 - 1555
反应条件
2: 45 percent / CuBr2 / acetonitrile / 7 h 3: 5 percent / TiCl4 / various solvent(s) / 96 h / 60 °C View Scheme
参考文献
Guenther, Erhard; Huenig, Siegfried
Chemische Berichte, 1992 , vol. 125, # 5 p. 1235 - 1242
反应条件
1: tin (IV)-chloride; carbon disulfide 2: potassium hexacyanoferrate(III); aqueous KOH-solution View Scheme
参考文献
Challenger; Gibson
Journal of the Chemical Society, 1940 , p. 305,308
反应条件
Behandeln des Reaktionsgemisches mit Kohlendioxid;
参考文献
Challenger; Gibson
Journal of the Chemical Society, 1940 , p. 305,308
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0°C; Inert atmosphere;
参考文献
Dogru, Mirjam; Handloser, Matthias; Auras, Florian; Kunz, Thomas; Medina, Dana; Hartschuh, Achim; Knochel, Paul; Bein, Thomas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 10 p. 2920 - 2924
Angew. Chem., 2013 , vol. 125, # 10 p. 2992 - 2996,5
反应条件
1: With n-butyllithium in tetrahydrofuran
T=0 - 20°C; 1 h; Inert atmosphere;
2: With copper dichloride in tetrahydrofuran
17 h; Inert atmosphereReflux;
参考文献
Ito, Hiroki; Yamamoto, Tatsuya; Yoshimoto, Noriyuki; Tsushima, Noboru; Muraoka, Hiroki; Ogawa, Satoshi
Heteroatom Chemistry, 2013 , vol. 24, # 1 p. 25 - 35
反应条件
1: Br2 / CHCl3
2: Zn; AcOH
3: MeONa; CuO; KI
View Scheme
参考文献
Turbiez, Mathieu; Frere, Pierre; Leriche, Philippe; Mercier, Nicolas; Roncali, Jean
Chemical Communications, 2005 , # 9 p. 1161 - 1163
