(3,5-二甲基异恶唑-4-基)乙酸合成路线 （共 5 条）
反应条件
lithium hydroxide hydrate in methanol T=20°C; 18 h;
参考文献
Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2773 - 2788
反应条件
lithium hydroxide hydrate in methanol T=20°C; 18 h;
参考文献
Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2773 - 2788
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C 1.2: 18 h 2.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 3 h / 78 °C 3.1: lithium hydroxide hydrate / methanol / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2773 - 2788
反应条件
1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 3 h / 78 °C 2: lithium hydroxide hydrate / methanol / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2773 - 2788
反应条件
1: hydroxylamine hydrochloride / water; methanol / 18 h / |Reflux 2: lithium hydroxide hydrate / methanol / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2773 - 2788
