2-碘-1,3,5-三甲氧基苯合成路线 （共 19 条）
反应条件
dihydrogen peroxide; iodine; 1-[4-N,N-bis(carboxylatomethyl)aminophenyltelluro]-3-phenoxypropane disodium salt in diethyl ether; water
T=20°C; pH=6; 5 h;
参考文献
Higgs; Nelen; Detty
Organic letters, 2001 , vol. 3, # 3 p. 349 - 352
反应条件
1: phloroglucinol trimethyl ether With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; 2 h;
3: methanol Further stages;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
sodium tetrahydroborate; diphenyltelluride in ethanol
T=0°C; 4 h;
参考文献
Vasil'ev, Andrei A.; Engman, Lars
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 3911 - 3917
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; Arylation; 2 h;
参考文献
Chang Ho Oh; Joo Sung Kim; Hyung Hoon Jung
Journal of Organic Chemistry, 1999 , vol. 64, # 4 p. 1338 - 1340
反应条件
1: 72 percent / MeONa / dimethylformamide / Ambient temperature
2: 81 percent / Ph2Te, NaBH4 / ethanol / 4 h / 0 °C
View Scheme
参考文献
Vasil'ev, Andrei A.; Engman, Lars
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 3911 - 3917
反应条件
copper; triethylamine in dichloromethane
18 h; Ambient temperature; Yield given;
参考文献
Hickey, Deirdre M. B.; Leeson, Paul D.; Novelli, Riccardo; Shah, Virendra P.; Burpitt, Brian E.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3103 - 3112
反应条件
1: copper bronze
2: 4.85 g / phosphoryl chloride / 2.75 h / Heating
3: 9.6 g / boron trichloride / CH2Cl2 / 1 h / -10 °C
4: 8.25 g / zinc amalgam, conc. hydrochloric acid / acetic acid; H2O / 2 h / Heating
5: 1.) hydrobromic acid, 2.) potassium carbonate / 1.) glacial acetic acid, reflux, 18 h, 2.) DMF, 24 h
View Scheme
参考文献
Sargent, Melvyn V.; Stransky, Peter O.; Patrick, Vincent A.; White, Allan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 2 p. 231 - 239
反应条件
ethylenediaminetetraacetic acid; copper
T=110 - 295°C; 4.5 h;
参考文献
Ragan, Mark A.
Canadian Journal of Chemistry, 1985 , vol. 63, p. 294 - 303
反应条件
1: 67 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 21 h / 80 °C
2: H2 / Raney Ni / methanol / 20 °C
3: 75 percent / TsOH*H2O / toluene / Heating
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
