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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
251294-64-1
合成路线
（共 9 条）
182120-82-7
→
反应条件
251294-64-1
反应条件
triethylamine; trifluoroacetic anhydride in dichloromethane T=0 - 20°C;
参考文献
Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7453 - 7463
71904-80-8
2-[[(叔丁氧羰基)氨基]甲基]噻唑-4-羧酸
→
反应条件
251294-64-1
反应条件
1: isobutyl chloroformate; aq. NH3; NMM / tetrahydrofuran 2: (CF3CO)2O; Et3N / CH2Cl2 View Scheme
参考文献
Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7453 - 7463
89226-13-1
2-氨基-2-硫代乙基氨基甲酸叔丁酯
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反应条件
251294-64-1
反应条件
1: CaCO3 / ethanol / 20 °C 2: isobutyl chloroformate; aq. NH3; NMM / tetrahydrofuran 3: (CF3CO)2O; Et3N / CH2Cl2 View Scheme
参考文献
Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7453 - 7463
35150-09-5
Boc-甘氨酰胺
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反应条件
251294-64-1
反应条件
1: Lawesson's reagent / 1,2-dimethoxy-ethane / 20 °C 2: CaCO3 / ethanol / 20 °C 3: isobutyl chloroformate; aq. NH3; NMM / tetrahydrofuran 4: (CF3CO)2O; Et3N / CH2Cl2 View Scheme
参考文献
Benelkebir, Hanae; Marie, Sabrina; Hayden, Annette L.; Lyle, Jason; Loadman, Paul M.; Crabb, Simon J.; Packham, Graham; Ganesan
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3650 - 3658
18598-63-5
L-半胱氨酸甲酯盐酸盐
+
85363-04-8
N-(叔丁氧羰基)-2-氨基乙腈
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反应条件
251294-64-1
反应条件
1: With triethylamine in methanol 2: With trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane Further stages;
参考文献
Schotes, Christoph; Ostrovskyi, Dmytro; Senger, Johanna; Schmidtkunz, Karin; Jung, Manfred; Breit, Bernhard
Chemistry - A European Journal, 2014 , vol. 20, # 8 p. 2164 - 2168
96929-05-4
2-((叔丁氧羰基氨基)甲基)噻唑-4-甲酸乙酯
→
反应条件
251294-64-1
反应条件
1: lithium hydroxide hydrate / water; methanol / |Inert atmosphere 2: ammonia / tetrahydrofuran; water / |Inert atmosphere 3: trifluoroacetic anhydride; triethylamine / dichloromethane / |Inert atmosphere View Scheme
参考文献
Li, Xianlin; Tu, Zhenchao; Li, Hua; Liu, Chunping; Li, Zheng; Sun, Qiao; Yao, Yiwu; Liu, Jinsong; Jiang, Sheng
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 132 - 136
297165-32-3
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反应条件
251294-64-1
反应条件
1.1: lithium hydroxide hydrate / tetrahydrofuran; water / 0 - 20 °C 1.2: pH 1 - 2 2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 0.17 h 3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 °C View Scheme
参考文献
Benelkebir, Hanae; Marie, Sabrina; Hayden, Annette L.; Lyle, Jason; Loadman, Paul M.; Crabb, Simon J.; Packham, Graham; Ganesan
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3650 - 3658
251294-64-1
→
反应条件
302341-70-4
2-(氨基甲基)-1,3-噻唑-4-甲腈
反应条件
1: With trimethylsilyl iodide in acetonitrile T=0°C; 0.5 h; Inert atmosphere; 2: With methanol in acetonitrile T=20°C; 0.166667 h; Inert atmospheresolid phase reaction;
参考文献
Souto, Jose A.; Vaz, Esther; Lepore, Ilaria; Poeppler, Ann-Christin; Franci, Gianluigi; Alvarez, Rosana; Altucci, Lucia; De Lera, Angel R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4654 - 4667
251294-64-1
→
反应条件
1009815-87-5
Largazole
反应条件
1.1: sodium hydrogencarbonate / methanol / 2 h / 70 °C / pH 6 / aq. phosphate buffer 2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C 2.2: 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C 4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; acetonitrile 5.1: triethylsilane; trifluoroacetic anhydride / 2 h / 0 - 20 °C 6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Patent: WO2009/105284 A1, 2009 ;
