5-溴-3-氟-2-羟基苯甲酸合成路线 （共 5 条）
反应条件
bromine in acetic acid T=20°C; 48 h;
参考文献
SGX Pharmaceuticals, Inc.
Patent: US2006/30583 A1, 2006 ;
Location in patent: Page/Page column 133-134 ;
US 20060030583 A1
反应条件
sodium chlorite; disodium hydrogenphosphate; aminosulfonic acid in 1,4-dioxane; water Oxidation; 0.5 h;
参考文献
Micklatcher, Mark L.; Cushman, Mark
Synthesis, 1999 , # 11 p. 1878 - 1880
反应条件
1: 78 percent / trifluoroacetic acid / 14 h / 90 °C 2: 81 percent / NaClO2; H2NSO3H; Na2HPO4*H2O / H2O; dioxane / 0.5 h View Scheme
参考文献
Micklatcher, Mark L.; Cushman, Mark
Synthesis, 1999 , # 11 p. 1878 - 1880
反应条件
hydrogen; potassium acetate; palladium on activated charcoal in acetic acid debromination; 12 h;
参考文献
Micklatcher, Mark L.; Cushman, Mark
Synthesis, 1999 , # 11 p. 1878 - 1880
反应条件
acetic acid in methanol; toluene
参考文献
SGX Pharmaceuticals, Inc.
Patent: US2006/30583 A1, 2006 ;
Location in patent: Page/Page column 133-134 ;
US 20060030583 A1
