1: 2-bromo-2'-isopropylbiphenyl With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: chloro-dicyclohexylphosphine in tetrahydrofuran; hexane Condensation; a) -78 deg C, 15 min, b) RT, 20 h;

1: 1-Bromo-2-isopropyl-benzene With magnesium in tetrahydrofuran T=60°C; Metallation; 2 h; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; Arylation; 2 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; Substitution; 22 h; Further stages.;

1.1: tetrakis(triphenylphosphine)palladium; K3PO4 / dimethylformamide / 48 h / 100 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 877 mg / tetrahydrofuran; hexane / a) -78 deg C, 15 min, b) RT, 20 h View Scheme

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: triisopropylborate / tetrahydrofuran; hexane / a) -78 deg C, 15 min, b) RT, overnight 1.3: 1 M aq. HCl / tetrahydrofuran; hexane / 0.25 h / 20 °C 2.1: tetrakis(triphenylphosphine)palladium; K3PO4 / dimethylformamide / 48 h / 100 °C 3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 3.2: 877 mg / tetrahydrofuran; hexane / a) -78 deg C, 15 min, b) RT, 20 h View Scheme

1.1: tetrakis(triphenylphosphine)palladium; K3PO4 / dimethylformamide / 48 h / 100 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 877 mg / tetrahydrofuran; hexane / a) -78 deg C, 15 min, b) RT, 20 h View Scheme