2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
sulfuric acid; potassium carbonate in ethanol
参考文献
Tularik Inc.
Patent: US6200995 B1, 2001 ;
反应条件
sulfuric acid; potassium nitrate T=90 - 100°C;
参考文献
Purgotti; Contardi
Gazzetta Chimica Italiana, 1902 , vol. 32 I, p. 531
反应条件
nitric acid; dinitrogen pentaoxide T=25°C; Product distribution;
参考文献
Moodie, Roy B.; Sanderson, Andrew J.; Willmer, Richard
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 5 p. 645 - 650
反应条件
1: With potassium tert-butylate in ethanol T=20°C; Inert atmosphereReflux; 2: With sodium sulfide; sulfur in ethanol; water 10 h; Inert atmosphereReflux; 3: With hydrogenchloride in ethanol; water T=20°C; pH=3 - 4;
参考文献
Tanikawa, Hiroharu; Ishii, Kazuhiro; Kubota, Shun; Sasanuma, Takashi; Yagai, Shiki; Kitamura, Akihide; Karatsu, Takashi
Heterocycles, 2010 , vol. 81, # 3 p. 659 - 674
反应条件
1: 85 percent / PCl5 / chlorobenzene / 1.) RT, 24 h, 2.) 50 deg C, 1 h 2: AlCl3 / 24 h / Ambient temperature View Scheme
参考文献
Bellamy; Chazan; Dodey; Dutartre; Ou; Pascal; Robin
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1545 - 1552
反应条件
1: 95 percent / H2 gas / platinic oxide / ethanol / Ambient temperature 2: 1.) NaNO2, 2N HCl; 2.) cuprous cyanide / 1.) water, 0 deg C, 35 min; 2.) water, 60 deg C, 40 min 3: SOCl2 / toluene / 1 h / 70 °C View Scheme
参考文献
Hino; Nakamura; Kato; Irie; Nagai; Uno
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3462 - 3467
反应条件
triethylamine in tetrahydrofuran
参考文献
Dr. Karl Thomae GmbH
Patent: US4829058 A1, 1989 ;
反应条件
copper; potassium carbonate in N,N-dimethyl-formamide
Ullmann-Goldberg condensation; 0.333333 h; sonication;
参考文献
Pellon, Rolando F.; Martin, Ana; Docampo, Maite L.; Mesa, Miriam
Synthetic Communications, 2006 , vol. 36, # 12 p. 1715 - 1719
反应条件
1: 160 °C
2: concentrated sulfuric acid / 88 °C
3: Na2S; ethanol
4: sodium-amalgam; aqueous NaOH
View Scheme
参考文献
Bogert et al.
Collection of Czechoslovak Chemical Communications, 1930 , vol. 2, p. 383,389
反应条件
1: 2-carboxy-4-nitro-chlorobenzene With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; 0.166667 h;
2: 2-amino-phenol in tetrahydrofuran
Heating; Further stages.;
参考文献
Kumar, Anil; Narasimhan, Balasubramanian; Kumar, Devinder
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4113 - 4124
