2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
1: SOCl2 / dimethylformamide / Heating
2: (i-Pr)2NEt / tetrahydrofuran / 48 h / 25 °C
View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: 85 percent / PCl5 / chlorobenzene / 1.) RT, 24 h, 2.) 50 deg C, 1 h
2: AlCl3 / 24 h / Ambient temperature
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参考文献
Kumazawa, Eiji; Hirotani, Kenji; Burford, S. Clifford; Kawagoe, Keiichi; Miwa, Tamotsu; Mitsui, Ikuo; Ejima, Akio
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1470 - 1474
反应条件
carbon disulfide; aluminium trichloride; phosphorus pentachloride
参考文献
Ullmann; Ernst
Chemische Berichte, 1906 , vol. 39, p. 300
参考文献
Reich, Siegfried Heinz; Bleckman, Ted Michael; Kephart, Susan Elizabeth; Romines, William Henry; Wallace, Michael B.
Patent: US2002/161022 A1, 2002 ;
反应条件
1: iron; aqueous hydrochloric acid
2: aqueous sodium carbonate-solution
View Scheme
参考文献
Goldberg; Kelly
Journal of the Chemical Society, 1946 , p. 102,107
反应条件
1: potassium carbonate; copper (II)-oxide / 120 °C
2: phosphoryl chloride
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参考文献
Drosdow; Drosdow
Zhurnal Obshchei Khimii, 1934 , vol. 4, p. 1
Chem. Zentralbl., 1934 , vol. 105, # II p. 3762
反应条件
1: 170 °C
2: tin; hydrochloric acid
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参考文献
Kahn
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 270
反应条件
1: 150 °C
2: ferrosulfate; ammonia
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参考文献
Kaufmann
Justus Liebigs Annalen der Chemie, 1894 , vol. 279, p. 287
反应条件
1: 97 percent / H2 / Pt
2: 1) NaNO2
3: 87 percent / NaOH
4: 73.4 percent / K2CO3 / Cu powder / 2 h / 160 °C
5: 93.6 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: 97 percent / H2 / Pt
2: 1) NaNO2
3: 87 percent / NaOH
4: 49.8 percent / K2CO3 / Cu powder / 2 h / 160 °C
5: CH3OK
6: 69.8 percent / CH3OK / 2 h / 140 °C
7: 92 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
