2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
sulfuric acid 24 h; Heating / reflux;
参考文献
Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 119 ;
反应条件
hydrogenchloride; methanol
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5382590 A1, 1995 ;
参考文献
Nagarajan,K. et al.
Indian Journal of Chemistry, 1974 , vol. 12, p. 236 - 246
反应条件
ammonia; potassium carbonate; copper(I) bromide in N,N-dimethyl-formamide T=150°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 13 p. 1483 - 1486
反应条件
1: SOCl2 / dimethylformamide / Heating 2: (i-Pr)2NEt / tetrahydrofuran / 48 h / 25 °C 3: 2N aq. NaOH / 10 h / Heating 4: NaH / dimethylformamide / Ambient temperature 5: 88 percent / H2 / 10percent Pd/C / ethanol / 16 h / 2585.7 Torr 6: 1.) 35percent aq. H2SO4, NaNO2, 2.) Cu(NO3)2*2.5H2O, CuO / 1.) 0 deg C, 30 min, 2.) water, 15 min View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: SOCl2 / dimethylformamide / Heating 2: (i-Pr)2NEt / tetrahydrofuran / 48 h / 25 °C 3: KOMe / various solvent(s) / 275 °C 4: NaH / dimethylformamide / Ambient temperature View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: SOCl2 / dimethylformamide / Heating 2: (i-Pr)2NEt / tetrahydrofuran / 48 h / 25 °C 3: 2N aq. NaOH / 10 h / Heating 4: NaH / dimethylformamide / Ambient temperature 5: 88 percent / H2 / 10percent Pd/C / ethanol / 16 h / 2585.7 Torr View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
1: potassium tert-butylate / ethanol / 20 °C 2: oxygen; copper diacetate; silver carbonate / N,N-dimethyl-formamide / 18 h / 145 °C View Scheme
参考文献
Bhadra, Sukalyan; Dzik, Wojciech I.; Goossen, Lukas J.
Journal of the American Chemical Society, 2012 , vol. 134, # 24 p. 9938 - 9941
反应条件
ethanol; sodium acetate
参考文献
Chemische Berichte, , vol. 34, p. 1155
参考文献
Chemische Berichte, , vol. 34, p. 1155
