2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
1: 89 percent / ethanol / 7 h / Heating 2: 79 percent / H2 / 10 percent Pd/C / dimethylformamide / 1 h / 20 °C / 750.06 Torr View Scheme
参考文献
Grell, Wolfgang; Hurnaus, Rudolf
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5219 - 5246
反应条件
1: SOCl2 / dimethylformamide / Heating 2: (i-Pr)2NEt / tetrahydrofuran / 48 h / 25 °C 3: 2N aq. NaOH / 10 h / Heating 4: H2 / 10percent Pd/C / ethanol / 16 h / 2585.7 Torr View Scheme
参考文献
Klunder, Janice M.; Hargrave, Karl D.; West, MaryAnn; Cullen, Ernest; Pal, Kollol; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1887 - 1897
反应条件
sodium hydroxide; zinc beim Erhitzen der erhaltenen 4.4'-Dichlor-azobenzol-dicarbonsaeure-(3.3') mit Kupfer und wss. Natronlauge auf 150grad;
参考文献
I.G.Farbenind.
Patent: CH164196 , 1932 ;
反应条件
1: SOCl2 / 1.5 h / Heating 2: 2.) water, concd. H2SO4 / 1.) ether, THF, ethanol, reflux, 2 h; 2.) acetic acid, reflux, 4 h View Scheme
参考文献
Pieper; Seydel; Kruger; Noll; Keck; Wiese
Arzneimittel-Forschung/Drug Research, 1989 , vol. 39, # 9 p. 1073 - 1080
反应条件
1: potassium carbonate; copper (II)-oxide / 120 °C 2: phosphoryl chloride 3: SnCl2; aq.-ethanolic HCl View Scheme
参考文献
Drosdow; Drosdow
Zhurnal Obshchei Khimii, 1934 , vol. 4, p. 1
Chem. Zentralbl., 1934 , vol. 105, # II p. 3762
反应条件
T=80°C; 0.0833333 h; microwave irradiation;
参考文献
Baqi, Younis; Mueller, Christa E.
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5908 - 5911
参考文献
CELL THERAPEUTICS, INC.
Patent: US2002/107269 A1, 2002 ;
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Cell Therapeutics, Inc.
Patent: US2003/153570 A1, 2003 ;
反应条件
1: 2-carboxy-4-nitro-chlorobenzene With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 0.166667 h; 2: aniline Heating; Further stages.;
参考文献
Kumar, Anil; Narasimhan, Balasubramanian; Kumar, Devinder
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4113 - 4124
参考文献
Kumar, Pradeep; Narasimhan, Balasubramanian; Yogeeswari, Perumal; Sriram, Dharmarajan
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 6085 - 6089
