反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -50 deg C, 1.5 h, 2.) Et2O, from -50 deg C to RT 2: SOCl2, DMF / 3 h / Heating 3: AlCl3 / CCl4 / 15 h / 85 °C 4: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 5: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
