ammonium formate; 1,2-bis-(diphenylphosphino)ethane; bis(dibenzylideneacetone)-palladium(0) in dimethyl sulfoxide T=50°C; deprotection; 12 h;

1: ethyl 4-quinolylmethyl butanedioate With ammonium formate; 1,2-bis-(diphenylphosphino)ethane; bis(dibenzylideneacetone)-palladium(0) in dimethyl sulfoxide T=50°C; Reduction; Deprotection; 12 h; 2: methyl iodide With sodium carbonate in water; dimethyl sulfoxide T=20°C; Methylation; 12 h;

1: Pd(dba)2; dppe; H4NOCOH / dimethylsulfoxide / 12 h / 50 °C 2: Na2CO3 / dimethylsulfoxide / 12 h / 20 °C View Scheme