4-氯噻吩并[2,3-c]吡啶-2-羧酸甲酯合成路线 （共 3 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
AMGEN INC.
Patent: WO2009/11871 A2, 2009 ;
Location in patent: Page/Page column 130-131 ;
WO 2009/011871 A2
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 1.2: 90 percent / tetrahydrofuran / 1.4 h / -78 °C 2.1: K2CO3 / dimethylformamide / 2 h / 60 °C View Scheme
参考文献
Stewart; Bhatia; McCarty; Patel; Staeger; Arendsen; Gunawardana; Melcher; Zhu; Boyd; Fry; Cool; Kiflie; Lartey; Marsh; Kempf-Grote; Kilgannon; Wisdom; Meyer; Gallatin; Okasinskit
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 988 - 1002
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=4;
参考文献
AMGEN INC.
Patent: WO2009/11871 A2, 2009 ;
Location in patent: Page/Page column 130; 131 ;
WO 2009/011871 A2
