2-氰基-3-甲基-5-氨基吡啶合成路线 （共 5 条）
反应条件
iron; calcium chloride in ethanol T=20°C; Reduction; 18 h;
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
反应条件
Calcium chloride in ethanol
参考文献
US2004/77605 A1, ;
US 20040077605 A1
反应条件
1: 57 percent / tetrabutylammonium nitrate; TFAA; t-butyl methyl ether / 60 h / 20 °C 2: 85 percent / Fe; CaCl2 / aq. ethanol / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1845 - 1855
反应条件
hydrogenchloride; sodium nitrite in water
参考文献
Cytovia, Inc.
Patent: US2004/127521 A1, 2004 ;
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; Diazotization; 1 h; 2: With copper Substitution; 0.5 h; Heating;
参考文献
Afonso, Adriano; Weinstein, Jay; Kelly, Joseph; Wolin, Ronald; Rosenblum, Stuart B.; Connolly, Michael; Guzi, Timothy; James, Linda; Carr, Donna; Patton, Robert; Bishop, W.Robert; Kirshmeier, Paul; Liu; Heimark; Chen; Nomeir
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1845 - 1855
