2,4-二羟基-6-甲基甲酸乙酯合成路线 （共 47 条）
反应条件
1: 100 percent / conc. H2SO4 / 0.5 h / Ambient temperature 2: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C 3: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr 4: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 81 percent / K2CO3 / acetone / 12 h / Heating 2: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT View Scheme
参考文献
Bruce, Ian; Spencer, Robert; Tyman, John
Journal of Chemical Research, Miniprint, 1992 , # 7 p. 1773 - 1795
反应条件
1: 98 percent / K2CO3 / acetone / Heating
2: 1.) LDA, 2.) acetaldehyde / 1.) THF, hexane-78 deg C, 30 min, 2.) THF, hexane, a.) -78deg C, 1 h, b.) RT, overnight
View Scheme
参考文献
Barbier; Devys
Synthetic Communications, 1992 , vol. 22, # 19 p. 2757 - 2762
反应条件
1: tetrachloromethane; chlorine
2: aqueous KOH
View Scheme
参考文献
Nolan; Murphy
Scientific Proceedings of the Royal Dublin Society, 1940 , vol. 22, p. 315,317
反应条件
1: 100 percent / conc. H2SO4 / 0.5 h / Ambient temperature
2: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C
3: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr
4: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
5: 85 percent / K2CO3 / acetone / 12 h / Heating
View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
potassium carbonate in acetone
3 h; Heating;
参考文献
Gramatica, Paola; Gianotti, M. Pia; Speranza, Giovanna; Manitto, Paolo
Heterocycles, 1986 , vol. 24, # 3 p. 743 - 750
反应条件
diisopropylamine in hexane; acetonitrile
T=20°C;
参考文献
EISAI CO. LTD.
Patent: WO2003/76424 A1, 2003 ;
Location in patent: Page/Page column 182 ;
参考文献
Fischer,E.; Hoesch
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 368,369
反应条件
1: 98 percent / potassium carbonate / acetone / 3 h / Heating
2: 1.) sodium hydride / 1.) benzene, 80 deg C, 1 h, 2.) benzene, a) 35 deg C, b) 45 to 50 deg C, 1 h
3: 68 percent / piperidine / toluene / 5 h / Heating
4: 95 percent / 0.2 N HCl / dioxane / 6 h / 80 °C
View Scheme
参考文献
Gramatica, Paola; Gianotti, M. Pia; Speranza, Giovanna; Manitto, Paolo
Heterocycles, 1986 , vol. 24, # 3 p. 743 - 750
反应条件
1: concentrated sulfuric acid
2: aqueous KOH-solution
3: quinoline; copper-powder
View Scheme
参考文献
Sastry; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1940 , # 12 p. 498,500, 504
