5-碘-1,2,3-三甲氧基苯合成路线 （共 37 条）
反应条件
tetrabutylammomium bromide; copper (II) acetate monohydrate in water T=20 - 140°C; Microwave irradiation;
参考文献
Ren, Yunlai; Wang, Wei; Zhao, Shuang; Tian, Xinzhe; Wang, Jianji; Yin, Weiping; Cheng, Lin
Tetrahedron Letters, 2009 , vol. 50, # 32 p. 4595 - 4597
反应条件
tetrabutylammomium bromide; copper (II) acetate monohydrate in water T=180°C; 22 h;
参考文献
Ren, Yunlai; Zhao, Shuang; Tian, Xinzhe; Liu, Zhifei; Wang, Jianji; Yin, Weiping
Letters in Organic Chemistry, 2009 , vol. 6, # 7 p. 564 - 567
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 2.) -78 deg C; Yield given. Multistep reaction;
参考文献
Hoye, Thomas R.; Kaese, Paul A.
Synthetic Communications, 1982 , vol. 12, # 1 p. 49 - 52
反应条件
copper bronze 1.) 240 deg C, 0.5 h, 2.) from 240 deg C to 280 deg C, 0.5 h; Further byproducts given;
参考文献
Australian Journal of Chemistry, , vol. 34, # 4 p. 799 - 817
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; iodobenzene; sodium t-butanolate 1 h; Inert atmosphereReflux; stereoselective reaction;
参考文献
Roche, Maxime; Frison, Gilles; Brion, Jean-Daniel; Provot, Olivier; Hamze, Abdallah; Alami, Mouad
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8485 - 8495
反应条件
tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butylate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane; dichloromethane T=90°C; 5 h; Sealed vessel;
参考文献
Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Rodrigo, Jordi; Bignon, Jerome; Wdzieczak-Bakala, Joanna; Desravines, Deborah; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad
European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 22 - 32
反应条件
1: Pd2(PPh3)2Cl2; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C 2: potassium carbonate / methanol / 3 h / 20 °C 3: hydrogen; C21H10F12NOP; [rhodium(I)(carbonyl)2(acetylacetonate)] / toluene / 20 h / 55 °C / 3750.38 Torr View Scheme
参考文献
Agabekov, Vladislav; Seiche, Wolfgang; Breit, Bernhard
Chemical Science, 2013 , vol. 4, # 6 p. 2418 - 2422
反应条件
1: Pd2(PPh3)2Cl2; copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C 2: potassium carbonate / methanol / 3 h / 20 °C 3: hydrogen; C21H10F12NOP; [rhodium(I)(carbonyl)2(acetylacetonate)] / toluene / 20 h / 55 °C / 3750.38 Torr 4: sodium tetrahydroborate; cerium(III) chloride / methanol; dichloromethane / 1.5 h / 0 °C View Scheme
参考文献
Agabekov, Vladislav; Seiche, Wolfgang; Breit, Bernhard
Chemical Science, 2013 , vol. 4, # 6 p. 2418 - 2422
反应条件
1: With tert.-butyl lithium in tetrahydrofuran T=-78°C; 2: With boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; Further stages.;
参考文献
Fukuda, Tsutomu; Sudo, Ei-ichi; Shimokawa, Kozue; Iwao, Masatomo
Tetrahedron, 2008 , vol. 64, # 2 p. 328 - 338
反应条件
1: 5-iodo-1,2,3-trimethoxybenzene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran T=-78°C; 1 h;
参考文献
Wan, Jung-Chih; Huang, Jun-Min; Jhan, Yu-Huei; Hsieh, Jen-Chieh
Organic Letters, 2013 , vol. 15, # 11 p. 2742 - 2745
