4-氨基-1-(5-乙氧基羰基吡啶-2-基)哌啶合成路线 (共 3 条)
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80 - 100°C; 4 h;
参考文献
Taiho Pharmaceutical Co., Ltd.
Patent: EP2527340 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With water; bis-[(trifluoroacetoxy)iodo]benzene in acetonitrile T=65°C; 30 h; 2: With hydrogenchloride in water; acetonitrile pH=1; 3: With sodium carbonate in water pH=8 - 9;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/121923 A1, 2007 ;
Location in patent: Page/Page column 88 ;
WO 2007/121923 A1
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/97260 A1, 2006 ;
Location in patent: Page/Page column 49-50 ;
WO 2006/097260 A1