2-甲基-1,2-苯并噻唑-3-酮合成路线 （共 65 条）
反应条件
potassium carbonate
T=158°C; 7 h; Sealed tube; Temperature;
参考文献
ROHM AND HAAS COMPANY; DOW GLOBAL TECHNOLOGIES LLC; STEPHENS, Randall W.; EMONDS, Mark V. M.; HENTON, Daniel R.
Patent: WO2014/85138 A1, 2014 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With sulfur; [2,2']bipyridinyl; copper(l) iodide; potassium carbonate in 1-methyl-pyrrolidin-2-one
T=110°C; 24 h; Inert atmosphere;
2: With pyridine; N-methoxyamine hydrochloride in 1-methyl-pyrrolidin-2-one
T=110°C; 3 h; Inert atmosphere;
参考文献
Krasikova; Katkevics
Chemistry of Heterocyclic Compounds, 2013 , vol. 48, # 11 p. 1684 - 1690
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 11 p. 1800 - 1807
反应条件
1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; 1,10-phenanthroline; tetra-(n-butyl)ammonium iodide in water
T=20 - 160°C; 48.5 h; Inert atmosphere;
参考文献
Wang, Fei; Chen, Chao; Deng, Geng; Xi, Chanjuan
Journal of Organic Chemistry, 2012 , vol. 77, # 8 p. 4148 - 4151
反应条件
in dichloromethane
T=-15 - 20°C; 2 h;
参考文献
Pietka-Ottlik, Magdalena; Potaczek, Piotr; Piasecki, Egbert; Mlochowski, Jacek
Molecules, 2010 , vol. 15, # 11 p. 8214 - 8228
反应条件
thionyl chloride in tetrachloromethane
5 h; Heating;
参考文献
Uchida, Yuzuru; Oae, Shigeru
Gazzetta Chimica Italiana, 1987 , vol. 117, # 11 p. 649 - 654
反应条件
1.1: TEA / dioxane
2.1: BOP; DIPEA / dimethylformamide
3.1: MCPBA / CHCl3
4.1: HMPA; n-BuLi / tetrahydrofuran / 0.17 h / -78 °C
4.2: 90 percent / tetrahydrofuran / -78 °C
5.1: CDCl3 / 31.85 °C
View Scheme
参考文献
Volonterio, Alessandro; Zanda, Matteo
Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8723 - 8726
反应条件
tetrachloromethane; chlorine
Eintragen des Reaktionsprodukts in waessr. Methylamin-Loesung;
参考文献
McClelland; Gait
Journal of the Chemical Society, 1926 , p. 923
反应条件
1: 76 percent / AlMe3 / CH2Cl2; toluene / 0 - 60 °C
2: 60 percent / phenyliodine(III)-bis(trifluoroacetate); TFA / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; SanMartin, Raul
Organic Letters, 2006 , vol. 8, # 21 p. 4811 - 4813
反应条件
1.1: MCPBA / CHCl3 / 1 h / 0 °C
2.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C
2.2: 74 percent / tetrahydrofuran / -78 °C
3.1: TFAA; TMP / CH2Cl2 / 0 °C
View Scheme
参考文献
Volonterio, Alessandro; Bravo, Pierfrancesco; Zanda, Matteo
Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6537 - 6540
反应条件
1.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C
1.2: 74 percent / tetrahydrofuran / -78 °C
2.1: TFAA; TMP / CH2Cl2 / 0 °C
View Scheme
参考文献
Volonterio, Alessandro; Bravo, Pierfrancesco; Zanda, Matteo
Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6537 - 6540
