2-甲基-1,2-苯并噻唑-3-酮合成路线 （共 65 条）
反应条件
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.83 h / 0 °C
3.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
3.2: 5.5 h / -70 - 20 °C / Inert atmosphere
4.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; oxalyl dichloride / dichloromethane / -50 °C / Inert atmosphere
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; (1R,2R)-(+)-1,2-diphenyl-1,2-ethanediol; water / tetrachloromethane / 20 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: 2-(4-methoxybenzylthio)-N-methylbenzamide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 1,4-dioxane
2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C
3.1: potassium hydroxide / ethanol / Reflux
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
5.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
5.2: -78 °C / Inert atmosphere
6.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: triethylamine
2.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; (1R,2R)-(+)-1,2-diphenyl-1,2-ethanediol; water / tetrachloromethane / 20 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
3.2: -78 °C / Inert atmosphere
4.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
1.1: triethylamine / 1,4-dioxane / 0.17 h / 0 °C
2.1: 2-(4-methoxybenzylthio)-N-methylbenzamide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 1,4-dioxane
3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C
4.1: potassium hydroxide / ethanol / Reflux
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
6.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
6.2: -78 °C / Inert atmosphere
7.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
tetrachloromethane
durch Bromierung und Kochen des Reaktionsprodukts mit Eisessig;
参考文献
Reissert; Manns
Chemische Berichte, 1928 , vol. 61, p. 1312
