7-苯磺酰基-4-氯-6-甲基-7H-吡咯并[2,3-d]嘧啶合成路线 （共 5 条）
反应条件
1: 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran T=-78°C; 0.05 h; 2: methyl iodide in tetrahydrofuran T=20°C; 4 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael
Patent: WO2013/191965 A1, 2013 ;
Location in patent: Page/Page column 191 ;
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / 0 °C 1.2: 1 h / 0 - 20 °C 2.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran / 0.05 h / -78 °C 2.2: 1 h / -78 - 20 °C View Scheme
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C 1.2: 1 h / 20 °C 2.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 0.05 h / -78 °C 2.2: 4 h / 20 °C View Scheme
参考文献
WO2012/158795 A1, ;
WO 2012/158795 A1
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C 1.2: 1 h / 20 °C 2.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 0.05 h / -78 °C 2.2: 4 h / 20 °C View Scheme
参考文献
WO2012/158795 A1, ;
WO 2012/158795 A1
反应条件
potassium tert-butylate in tetrahydrofuran 16 h;
参考文献
Sunesis Pharmaceuticals, Inc
Patent: US2009/5359 A1, 2009 ;
Location in patent: Page/Page column 26 ;
US 20090005359 A1
