甲基5-溴-3-甲基-2-糠酸酯合成路线 （共 5 条）
反应条件
bromine in diethyl ether T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; WASHBURN, William N.; MIGNONE, James
Patent: WO2010/42674 A1, 2010 ;
Location in patent: Page/Page column 115 ;
WO 2010/042674 A1
参考文献
Knight, David W.; Rustidge, David C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 679 - 683
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; 1 h;
参考文献
Tsubuki, Masayoshi; Takahashi, Kazunori; Honda, Toshio
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10183 - 10186
反应条件
1: 84 percent / Pd(PPh3)4 / tetrahydrofuran / 1 h / 20 °C
2: 80 percent / DIBAL / CH2Cl2; hexane / 1 h / -78 °C
View Scheme
参考文献
Tsubuki, Masayoshi; Takahashi, Kazunori; Honda, Toshio
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10183 - 10186
反应条件
1: 84 percent / Pd(PPh3)4 / tetrahydrofuran / 1 h / 20 °C
2: 80 percent / DIBAL / CH2Cl2; hexane / 1 h / -78 °C
3: acetonitrile / 13 h / 20 °C
4: 1.015 g / γ-collidine / CH2Cl2 / 1 h / -78 °C
5: 89 percent / DIBAL / CH2Cl2; hexane / 1 h / -78 °C
6: 93 percent / MsCl; LiCl; 2,6-lutidine / dimethylformamide / 2 h / -5 °C
7: 98 percent / TBAF / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Tsubuki, Masayoshi; Takahashi, Kazunori; Honda, Toshio
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10183 - 10186
