乙基3-(3,4-二氟苯基)-3-氧代丙酸酯合成路线 （共 2 条）
反应条件
1: 3,4-difluoro-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
0.5 h; Heating;
2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran
T=20°C; Further stages.;
参考文献
Jae; Winn; Von Geldern; Sorensen; Chiou; Nguyen; Marsh; Opgenorth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3978 - 3984
反应条件
sodium hydride in tetrahydrofuran
参考文献
Jae, Hwan-Soo; Winn, Martin; Dixon, Douglas B.; Marsh, Kennan C.; Nguyen, Bach; Opgenorth, Terry J.; Von Geldern, Thomas W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 20 p. 3217 - 3227
