2,6-二氯-4-苯基吡啶合成路线 （共 5 条）
反应条件
1: bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: With zinc(II) chloride in tetrahydrofuran; hexane 0.25 h; 3: 2,6-dichloro-4-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Negishi coupling; 16 h; Heating;
参考文献
Fang, Albert G.; Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2003 , vol. 5, # 7 p. 967 - 970
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 4 h;
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
反应条件
1.1: hydrochloric acid; sodium nitrite / acetonitrile; H2O / 0.08 h / cooling 1.2: 52 percent / potassium iodide / acetonitrile; H2O 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: zinc chloride / tetrahydrofuran; hexane / 0.25 h 2.3: 98 percent / tetrakis(triphenylphosphine)palladium(0) / tetrahydrofuran; hexane / 16 h / Heating View Scheme
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
反应条件
in neat (no solvent) T=140°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Tutonda, M.; Vanderzande, D.; Vekemans, J.; Toppet, S.; Hoornaert, G.
Tetrahedron Letters, 1986 , vol. 27, # 22 p. 2509 - 2512
反应条件
1: 95 percent / NaH / dimethylformamide; various solvent(s) / 4 h / 90 °C 2: H2 / Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Mello, Jesse V.; Finney, Nathaniel S.
Organic Letters, 2001 , vol. 3, # 26 p. 4263 - 4265
