potassium fluoride in acetonitrile T=20°C; Substitution; 96 h;

1.1: KOH / methanol 1.2: 92 percent / dimethylsulfoxide / 6 h / 60 °C 2.1: 97 percent / aq. Na2S2O4; NaHCO3 / dimethylformamide / 4 h / 65 - 75 °C 3.1: 97 percent / Cl2; H2O / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h 4.1: 90 percent / KF / acetonitrile / 96 h / 20 °C View Scheme