反应条件
1: triethylamine; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF6(1-) / CH2Cl2 / 18 h / 20 °C
2: 26.1 g / hydrochloric acid / ethyl acetate / 3 h / -10 - 20 °C
3: 99 percent / CH2Cl2 / 18 h / 20 °C
4: 380 mg / trifluoroacetic acid / 0.67 h / 50 °C
View Scheme
参考文献
Henderson, Elisa A.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Joanna; Carter, Malcolm C.; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Fraser, Ian J.; Harris, Robert A.; Keegan, Sally J.; Kelsey, Richard D.; Lumley, James A.; Stables, Jeremy N.; Weerasekera, Natasha; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1685 - 1692