1: With sodium hydride in tetrahydrofuran T=20°C; 2.833 h; 2: With acetic acid in tetrahydrofuran T=0°C; 0.166667 h; 3: With sodium hydrogencarbonate in water
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/139941 A1, 2008 ;
Location in patent: Page/Page column 102 ;
WO 2008/139941 A1
