253185-03-4合成路线 （共 388 条）
反应条件
1: AlCl3
2: aqueous nitric acid
View Scheme
参考文献
Barbier
Helvetica Chimica Acta, 1936 , vol. 19, p. 1345,1350
反应条件
n-butyllithium; potassium tert-butylate
1) hexane, 2h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Schlosser, Manfred; Choi, Jung Hoon; Takagishi, Sadahito
Tetrahedron, 1990 , vol. 46, # 16 p. 5633 - 5648
反应条件
aluminium trichloride; urea
T=0 - 5°C; 3 h;
参考文献
Freyer, Wolfgang
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 8 p. 690 - 692
反应条件
byproducts: isobutan, boron hydride; High Pressure; under N2; diborane and trihalogen-borane was added to t-butylbenzene at-130°C, then in a closed autoclave the mixture was heated to 130°C for 40 min; at -195.8°C H2 was removed, at room temp. the residue of trihalogen-borane and diborane were removed, unseparable isomers; elem. anal.;
参考文献
Paetzold, Peter; Hoffmann, Juergen
Chemische Berichte, 1980 , vol. 113, # 12 p. 3724 - 3733
反应条件
aluminium trichloride; nitrobenzene
参考文献
Vingiello; Bradsher
Journal of the American Chemical Society, 1949 , vol. 71, p. 3572
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / |Inert atmosphere
1.2: Friedel-Crafts Acylation / 1.5 h / 0 - 5 °C / |Inert atmosphere
2.1: ammonia
3.1: water; methanol / 1 h / 65 °C / |Large scale
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatramani; Leanna
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 578 - 584
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.25 h / 0 °C
1.2: 1.25 h / 0 °C
1.3: Cooling with ice
2.1: sulfuric acid / dichloromethane / 2 h / 90 °C
3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / Reflux
4.1: potassium tert-butylate / tetrahydrofuran / 20 °C
4.2: 0 - 20 °C
5.1: hydrogen; ammonia / palladium 10 on activated carbon / methanol / 6 h / 3102.97 Torr
6.1: (R)-N-acetylleucine / methanol / 1 h / 65 °C
View Scheme
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; FRORMANN, Sven
Patent: WO2012/62463 A1, 2012 ;
反应条件
manganese triacetate in various solvent(s)
2 h; ultrasonic irradiation; Product distribution; Further Variations:Solvents;
参考文献
Yinghuai, Zhu; Bahnmueller, Stefan; Hosmane, Narayan S.; Maguire, John A.
Chemistry Letters, 2003 , vol. 32, # 8 p. 730 - 731
反应条件
1: 57 percent / AlCl3 / various solvent(s)
2: NH2NH2*H2O, KOH / ethane-1,2-diol / 3 h / Heating
3: KOH / ethane-1,2-diol / 12 h / Heating
4: PCl5 / benzene / 0.08 h / Heating
5: SnCl4 / benzene / 6 h / 0 °C
6: 31 percent / diethyl ether / 0.5 h / Heating
7: 80 percent / HCO2H
8: 61 percent / 10percent Pd/C / 0.75 h / 260 - 290 °C
View Scheme
参考文献
Jackson, Richard A.; Rhodes, Christopher J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 1 p. 53 - 57
反应条件
aluminium trichloride
1 h;
参考文献
Gonzalez, Silvia; Pelaez, Rafael; Sanz, Francisca; Jimenez, Ma. Belen; Moran, Joaquin R.; Caballero, Ma. Cruz
Organic Letters, 2006 , vol. 8, # 21 p. 4679 - 4682
