3-[3-(溴甲基)苯基]-5-甲基-1,2,4-噁二唑合成路线 （共 6 条）
反应条件
phosphorus tribromide in toluene T=20 - 35°C; 3 h;
参考文献
US2011/269756 A1, ;
Page/Page column 25 ;
反应条件
N-bromosuccinmide in tetrachloromethane Bromination; 2 h; Irradiationreflux;
参考文献
Mederski, Werner W.K.R.; Lefort, Marina; Germann, Martina; Kux, Dieter
Tetrahedron, 1999 , vol. 55, # 44 p. 12757 - 12770
反应条件
1.1: potassium carbonate; hydroxylamine hydrochloride / methanol / 15 h / 40 °C / Reflux 2.1: acetic anhydride; acetic acid / water / 14 h / 118 °C 3.1: sulfuric acid / 18 h / Reflux 4.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C 4.2: pH 7 5.1: phosphorus tribromide / toluene / 3 h / 20 - 35 °C View Scheme
反应条件
1.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C 1.2: pH 7 2.1: phosphorus tribromide / toluene / 3 h / 20 - 35 °C View Scheme
反应条件
1.1: sulfuric acid / 18 h / Reflux 2.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C 2.2: pH 7 3.1: phosphorus tribromide / toluene / 3 h / 20 - 35 °C View Scheme
反应条件
1.1: acetic anhydride; acetic acid / water / 14 h / 118 °C 2.1: sulfuric acid / 18 h / Reflux 3.1: lithium borohydride / tetrahydrofuran / 20 h / 0 - 20 °C 3.2: pH 7 4.1: phosphorus tribromide / toluene / 3 h / 20 - 35 °C View Scheme
