1: 9,10-dihydro-5-methyl-9-oxo-4-acridinecarboxylic acid With thionyl chloride; N,N-dimethyl-formamide 0.666667 h; Heating / reflux; 2: N,N-dimethylethylenediamine With triethylamine in chloroform T=-10°C; 0.5 h;

1: cuprous chloride, N-ethylmorpholine / benzene; various solvent(s) / 1 h / 120 °C 2: polyphosphoric acid / 1 h / 120 °C 3: SOCl2 / 1 h / Heating 4: CH2Cl2 / 0.5 h / 20 °C View Scheme

1: cuprous chloride, N-ethylmorpholine / benzene; various solvent(s) / 1 h / 120 °C 2: polyphosphoric acid / 1 h / 120 °C 3: SOCl2 / 1 h / Heating 4: CH2Cl2 / 0.5 h / 20 °C View Scheme

in dichloromethane T=20°C; 0.5 h;

ammonia in various solvent(s) T=110 - 120°C; 0.25 h;