1.1: sodium cyanoborohydride / ethanol; acetic acid / 2 h / 23 °C / Inert atmosphere 1.2: 2 h / 23 °C / Inert atmosphere 2.1: 2,3-diphenylcyclopropenone; trifluoromethanesulfonic anhydride / dichloromethane / 3.5 h / 23 °C / Inert atmosphere View Scheme

1: With sodium hydroxide; potassium hydrogensulfate in methanol T=0 - 2°C; Hydrolysis; pH=7.15; 0.333333 h; 2: With sodium hydroxide; potassium hydrogensulfate in acetonitrile T=20°C; Substitution; 1 h; 3: With glucose dehydrogenase; beef liver glutamate dehydrogenase; nicotinamide adenine dinucleotide in water T=30°C; reductive amination; pH=8.75; 25 h; Enzymatic reaction;