2-氨基-6-甲基苯并噻唑合成路线 （共 70 条）
反应条件
sodium hydroxide 24 h; Heating;
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026
反应条件
potassium hydroxide T=130 - 150°C; 7 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 23, p. 317 - 326
Zhurnal Organicheskoi Khimii, , vol. 23, # 2 p. 355 - 365
反应条件
hydrogenchloride; hydrazine hydrate in ethylene glycol Microwave irradiation;
参考文献
Munirajasekhar; Himaja; Mali, Sunil V.
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 2 p. 459 - 465
反应条件
1: tert.-butylnitrite; copper(I) bromide / acetonitrile / 1 h / 60 °C 2: N-bromosuccinmide / tetrachloromethane / 4 h / Irradiation 3: silver nitrate / ethanol; water / 1.33 h / Reflux View Scheme
参考文献
Hrobarik, Peter; Hrobarikova, Veronika; Sigmundova, Ivica; Zahradnik, Pavol; Fakis, Mihalis; Polyzos, Ioannis; Persephonis, Peter
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8726 - 8736
参考文献
Gakhar, H. K.; Gupta, Shashi Bhushan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 681 - 682
参考文献
Mazumdar,A.K.D. et al.
Journal of the Indian Chemical Society, 1979 , vol. 56, p. 999 - 1001
反应条件
potassium hydroxide in isopropyl alcohol
参考文献
Fink, Brian E.; Gavai, Ashvinikumar V.; Tokarski, John S.; Goyal, Bindu; Misra, Raj; Xiao, Hai-Yun; Kimball, S. David; Han, Wen-Ching; Norris, Derek; Spires, Thomas E.; You, Dan; Gottardis, Marco M.; Lorenzi, Matthew V.; Vite, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1532 - 1536
反应条件
potassium hydroxide T=130 - 150°C; 7 h;
参考文献
Drozd, V.N.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 317 - 326
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 2 p. 355 - 365
反应条件
1: 90.8 percent / aq. NaOH / 24 h / Heating 2: 13.2 percent / 15 h / 150 - 160 °C 3: pyridine / 7 h / Ambient temperature 4: 82 percent / aq. NaOH / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 5: 94.8 percent / aq. K2CO3 / acetone / Heating 6: pyridine / 100 - 110 °C View Scheme
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026
反应条件
1: 54 percent / aq.potassium hydroxide (60 percent) / 7 h / 130 - 150 °C
2: 59 percent / triethylamine / diethyl ether / 0.25 h
View Scheme
参考文献
Drozd, V.N.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 317 - 326
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 2 p. 355 - 365
