2-氨基-6-甲基苯并噻唑合成路线 （共 70 条）
反应条件
1: 54 percent / aq.potassium hydroxide (60 percent) / 7 h / 130 - 150 °C
2: 59 percent / triethylamine / diethyl ether / 0.25 h
3: 80 percent / triethylamine / diethyl ether / standing overnight
View Scheme
参考文献
Wang, Jian; Zhang, Xiao-Zhuan; Chen, Shan-Yong; Yu, Xiao-Qi
Tetrahedron, 2014 , vol. 70, # 2 p. 245 - 250
反应条件
1: isopentyl nitrite / tetrahydrofuran / 0.5 h / |Reflux
2: FeCl3·6H2O; dipotassium peroxodisulfate / dimethyl sulfoxide; water / 12 h / 100 °C
View Scheme
参考文献
Wang, Jian; Zhang, Xiao-Zhuan; Chen, Shan-Yong; Yu, Xiao-Qi
Tetrahedron, 2014 , vol. 70, # 2 p. 245 - 250
参考文献
Mazumdar,A.K.D. et al.
Journal of the Indian Chemical Society, 1979 , vol. 56, p. 999 - 1001
反应条件
1: NaOH / H2O / Heating
2: 50 percent / dimethylsulfoxide / 1 h / Heating
View Scheme
参考文献
Kalwania; Chomal; Choudhary, Savita
Asian Journal of Chemistry, 2011 , vol. 23, # 11 p. 5133 - 5136
反应条件
1: NaOH / H2O / Heating
2: 75 percent / dimethylsulfoxide / 1 h / Heating
View Scheme
参考文献
Gupta, R. R.; Ojha, K. G.; Kalwania, G. S.; Kumar, M.
Heterocycles, 1980 , vol. 14, # 8 p. 1145 - 1149
反应条件
bromine in chloroform
T=20°C; 2 h;
参考文献
LUCKY, LTD.
Patent: EP590610 A1, 1994 ;
反应条件
piperidine in ethanol
T=70 - 80°C; 0.75 h;
参考文献
Dash, B.; Patra, M.; Praharaj, S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 10 p. 894 - 897
反应条件
1: 92 percent / Br / CHCl3 / 2 h / 20 °C
2: 65 percent / aq. sodium hydroxide / acetonitrile / 1 h / Heating
View Scheme
参考文献
Ra, Choon Sup; Jung, Bon Young; Park, Gyoosoon
Heterocycles, 2004 , vol. 62, p. 793 - 802
反应条件
in N,N-dimethyl-formamide
T=0 - 25°C; 14 h;
参考文献
PURDUE PHARMA L.P.; Shionogi and Co. Ltd.; TAFESSE, Laykea; ANDO, Shigeru; KUROSE, Noriyuki
Patent: WO2012/176061 A1, 2012 ;
Location in patent: Page/Page column 152 ;
WO 2012/176061 A1
反应条件
[{(η5-C5Me5)IrCl}2(μ-Cl)2]; sodium hydroxide
T=150°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Li, Feng; Shan, Haixia; Chen, Lin; Kang, Qikai; Zou, Po
Chemical Communications, 2012 , vol. 48, # 4 p. 603 - 605
