2-氨基-6-甲基苯并噻唑合成路线 （共 70 条）
反应条件
1: 76 percent / ethanol / 15 h / Heating
2: 50percent aq. KOH / Heating
3: 75 percent / sodium carbonate / ethanol / 10 h / Heating
View Scheme
参考文献
Lin; Kasina
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 759 - 761
反应条件
1: 76 percent / ethanol / 15 h / Heating
2: 50percent aq. KOH / Heating
3: 75 percent / sodium carbonate / ethanol / 10 h / Heating
4: 86 percent / copper powder, cuprous iodide, sodium carbonate / dimethylformamide / 12 h / Heating
View Scheme
参考文献
Lin; Kasina
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 759 - 761
反应条件
1: 76 percent / ethanol / 15 h / Heating
2: 50percent aq. KOH / Heating
3: 75 percent / sodium carbonate / ethanol / 10 h / Heating
4: 86 percent / copper powder, cuprous iodide, sodium carbonate / dimethylformamide / 12 h / Heating
5: stannous chloride, acetic anhydride, HCl (g) / acetic acid / Ambient temperature
6: 1. sodium nitrite / 1. 48percent fluoroboric acid, -5 degC, 1h; 2. ice cold, 1h; 3. 30 min.
View Scheme
参考文献
Lin; Kasina
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 759 - 761
反应条件
1: 2-amino-6-methyl-benzothiazole With triethylamine in dichloromethane
T=5°C; 0.25 h;
2: oxalic acid monoethyl ester chloride in dichloromethane
T=20°C;
参考文献
Navarrete-Vazquez, Gabriel; Ramirez-Martinez, Marleth; Estrada-Soto, Samuel; Nava-Zuazo, Carlos; Paoli, Paolo; Camici, Guido; Escalante-Garcia, Jaime; Medina-Franco, Jose L.; Lopez-Vallejo, Fabian; Ortiz-Andrade, Rolffy
European Journal of Medicinal Chemistry, 2012 , vol. 53, p. 346 - 355
反应条件
acetic acid in ethanol; water
Heating;
参考文献
Malik, Sachin; Bahare, Radhe Shyam; Khan, Suroor Ahmad
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 1 - 13
反应条件
1: diethyl ether / 40 - 60 °C
2: aq. HCl / 1 h / Heating
View Scheme
参考文献
Joshua,C.P.
Journal of the Indian Chemical Society, 1961 , vol. 38, # 12 p. 979 - 987
参考文献
Joshua,C.P.
Journal of the Indian Chemical Society, 1961 , vol. 38, # 12 p. 979 - 987
反应条件
in diethyl ether
T=40 - 60°C;
参考文献
Singh, A. P.; Bhattacharya, A.; Verma, V. K.
Journal of the Indian Chemical Society, 1990 , vol. 67, # 3 p. 223 - 225
Title/Abstract Full Text Show Details
Singh; Bhattacharya; Verma
Journal of the Indian Chemical Society, 1991 , vol. 68, # 8 p. 472 - 474
反应条件
2: aqueous HCl
View Scheme
参考文献
Takatori; Nishida
Yakugaku Zasshi, 1950 , vol. 70, p. 271,276
Chem.Abstr., 1951 , p. 10212
反应条件
(i) Py, (ii) NaOH, EtOH; Multistep reaction;
参考文献
Bhargava,P.N.; Sharma,S.C.
Bulletin of the Chemical Society of Japan, 1962 , vol. 35, # 6 p. 942 - 945
