1: With potassium tert-butylate in tetrahydrofuran
T=0 - 20°C;
2: With water in tetrahydrofuran
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/107334 A1, 2014 ;
Location in patent: Paragraph 0038-0040 ;
1: cyanomethyl-phosphonic acid diethyl ester With n-butyllithium in tetrahydrofuran
T=0°C; 0.75 h;
2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran
Wittig reaction; optical yield given as percent de;
参考文献
Sanders, Shanina D.; Ruiz-Olalla, Andrea; Johnson, Jeffrey S.
Chemical Communications, 2009 , # 34 p. 5135 - 5137
sodium hydride in tetrahydrofuran; mineral oil
T=0 - 20°C; Wittig reaction; 2 h;
参考文献
Halskov, Kim Soholm; Johansen, Tore Kiilerich; Davis, Rebecca L.; Steurer, Marianne; Jensen, Frank; Jorgensen, Karl Anker
Journal of the American Chemical Society, 2012 , vol. 134, # 31 p. 12943 - 12946
