C-(4-甲氧基-苯基)-c-苯基甲胺合成路线 （共 11 条）
反应条件
ammonia; [Rh(acac)(η2-C2H4)2]; (S,S)-methyl-DuPhos in 1,4-dioxane; water
T=80°C; 16 h;
参考文献
KANATA CHEMICAL TECHNOLOGIES INC.
Patent: WO2008/119162 A1, 2008 ;
Location in patent: Page/Page column 54-55; 65 ;
反应条件
1: With bis(η3-allyl-μ-chloropalladium(II)); cesium hydroxide monohydrate; tri-cyclo-hexyl-phosphine in anhydrous xylene
24 h; RefluxInert atmosphere;
2: With formic acid; sodium cyanoborohydride in ethanol; water
T=25°C; 2 h; Further stages;
参考文献
Niwa, Takashi; Suehiro, Takafumi; Yorimitsu, Hideki; Oshima, Koichiro
Tetrahedron, 2009 , vol. 65, # 26 p. 5125 - 5131
反应条件
in tetrahydrofuran
44 h; Heating;
参考文献
Hart, David J.; Kanai, Ken-ichi; Thomas, Dudley G.; Yang, Teng-Kuei
Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 289 - 294
反应条件
1: 96 percent / H2SO4 / 17 h / 20 °C
2: 100 percent / H2O; LiOH / acetonitrile / 3 h / 50 °C
View Scheme
参考文献
Laurent, Mathieu; Marchand-Brynaert, Jacqueline
Synthesis, 2000 , # 5 p. 667 - 672
反应条件
2: 56 percent / tetrahydrofuran / 44 h / Heating
View Scheme
参考文献
Hart, David J.; Kanai, Ken-ichi; Thomas, Dudley G.; Yang, Teng-Kuei
Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 289 - 294
反应条件
ammonia; lithium
1.) THF, reflux, 14 h, 2.) THF, 20 min; Yield given. Multistep reaction;
参考文献
Weiberth, Franz J.; Hall, Stan S.
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5338 - 5341
参考文献
Billon
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1926 , vol. 182, p. 471
Annales de Chimie (Cachan, France), 1927 , vol. <10>7, p. 337
参考文献
Hantzsch; Kraft
Chemische Berichte, 1891 , vol. 24, p. 3516
反应条件
T=200 - 220°C; und Behandeln des Reaktionsprodukts mit Chlorwasserstoff enthaltendem Aethanol;
参考文献
Ogata; Konishi; Hayashi
Yakugaku Zasshi, 1934 , vol. 54, p. 550,557
参考文献
Billon
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1926 , vol. 182, p. 471
Annales de Chimie (Cachan, France), 1927 , vol. <10>7, p. 337
