2,4-二甲基-5-醛基-1H-吡咯-3-羧酸合成路线 （共 23 条）
反应条件
methanol; water; potassium hydroxide T=100°C; 2 h;
参考文献
Lv, Kai; Wang, Li-Li; Liu, Ming-Liang; Zhou, Xin-Bo; Fan, Shi-Yong; Liu, Hong-Ying; Zheng, Zhi-Bing; Li, Song
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3062 - 3065
反应条件
potassium hydroxide in methanol; water
参考文献
SUGEN, INC.
Patent: US2004/209937 A1, 2004 ;
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in methanol; ethanol T=20°C; 5 h;
参考文献
Rastogi, Soumya; Marchal, Estelle; Uddin, Imam; Groves, Brandon; Colpitts, Julie; McFarland, Sherri A.; Davis, Jeffery T.; Thompson, Alison
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3834 - 3845
反应条件
1: 64 percent / TFA 2: 93 percent / aq. KOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1116 - 1119
反应条件
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C View Scheme
反应条件
1.1: hydrogenchloride / water; ethanol / 4 h / 0 - 65 °C 2.1: trichlorophosphate / dichloromethane / 15 h / 0 - 20 °C / |Inert atmosphere 2.2: 2 h / |Reflux 2.3: 1 h / |Reflux 3.1: palladium on activated charcoal; hydrogen; triethylamine / methanol; ethanol / 5 h / 760.05 Torr View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 23 p. 3834 - 3845
反应条件
1.1: trichlorophosphate / dichloromethane / 15 h / 0 - 20 °C / |Inert atmosphere 1.2: 2 h / |Reflux 1.3: 1 h / |Reflux 2.1: palladium on activated charcoal; hydrogen; triethylamine / methanol; ethanol / 5 h / 760.05 Torr View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 23 p. 3834 - 3845
反应条件
pyrrolidine in ethanol 3 h; Reflux;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 52, # 9 p. 360 - 365
反应条件
1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; 1-amino-2-diethylamino-ethane With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in tetrahydrofuran 20 h; 2: (-)-(S)-hydroxybutanedioic acid in tetrahydrofuran 4 - 6 h; Reflux; 3: 5-Fluoro-1,3-dihydro-2H-indol-2-one in tetrahydrofuran 4 - 6 h; Reflux; Product distribution / selectivity;
参考文献
Natco Pharma Limited
Patent: US2011/92717 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 1.2: 16 h / 25 - 30 °C 2.1: pyrrolidine / methanol / 5 - 7 h / Reflux 3.1: ethanol / 2 - 4 h / Reflux View Scheme
参考文献
SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD.; HENSCHKE, Julian, P.; CHEN, Yung-Fa
Patent: WO2012/58780 A1, 2012 ;
