2,4-二甲基-5-醛基-1H-吡咯-3-羧酸合成路线 (共 23 条)
反应条件
1: tetrahydrofuran / 45 °C 2: imidazole / carbon dioxide / tetrahydrofuran / 45 °C 3: 100 percent / H2O View Scheme
参考文献
Vaidyanathan, Rajappa; Kalthod, Vikram G.; Ngo, Duc P.; Manley, Jerad M.; Lapekas, Sean P.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2565 - 2568
参考文献
Sugen, Inc.
Patent: US2003/69297 A1, 2003 ;
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
48 h; RefluxInert atmosphere;
参考文献
Uddin, Md. Imam; Thirumalairajan, Srinath; Crawford, Sarah M.; Cameron, T. Stanley; Thompson, Alison
Synlett, 2010 , # 17 p. 2561 - 2564