3-碘-2-羟基-5-硝基吡啶合成路线 （共 8 条）
反应条件
iodine; sodium carbonate in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
Dolle, Frederic; Langle, Sandrine; Roger, Gaelle; Fulton, Roger R.; Lagnel-De Bruin, Beatrice; Henderson, David J.; Hinnen, Francoise; Paine, Taliesha; Coster, Mark J.; Valette, Heric; Bottlaender, Michel; Kassiou, Michael
Australian Journal of Chemistry, 2008 , vol. 61, # 6 p. 438 - 445
反应条件
KIO3; potassium iodide in sulfuric acid; water
参考文献
US2004/77605 A1, ;
US 20040077605 A1
反应条件
1: 78 percent / POCl3; quinoline / 2 h / 120 °C 2: 68 percent / iron; aq. AcOH / 65 - 85 °C View Scheme
参考文献
Brown, LaVerne L.; Kulkarni, Santosh; Pavlova, Olga A.; Koren, Andrei O.; Mukhin, Alexey G.; Newman, Amy H.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2841 - 2849
反应条件
quinoline; trichlorophosphate in N,N-dimethyl-formamide T=120°C; 2 h;
参考文献
Dolle, Frederic; Langle, Sandrine; Roger, Gaelle; Fulton, Roger R.; Lagnel-De Bruin, Beatrice; Henderson, David J.; Hinnen, Francoise; Paine, Taliesha; Coster, Mark J.; Valette, Heric; Bottlaender, Michel; Kassiou, Michael
Australian Journal of Chemistry, 2008 , vol. 61, # 6 p. 438 - 445
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
反应条件
1: 81.1 percent / POBr3 / toluene; quinoline / 90 - 100 °C 2: 74 percent / iron powder; aq. acetic acid / 70 - 72 °C View Scheme
参考文献
Zhang, Yi; Pavlova, Olga A.; Chefer, Svetlana I.; Hall, Andrew W.; Kurian, Varughese; Brown, LaVerne L.; Kimes, Alane S.; Mukhin, Alexey G.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2453 - 2465
反应条件
phosphorus oxytribromide in quinoline; toluene T=90 - 100°C;
参考文献
Zhang, Yi; Pavlova, Olga A.; Chefer, Svetlana I.; Hall, Andrew W.; Kurian, Varughese; Brown, LaVerne L.; Kimes, Alane S.; Mukhin, Alexey G.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2453 - 2465
反应条件
1.1: 78 percent / POCl3; quinoline / 2 h / 120 °C
2.1: 68 percent / iron; aq. AcOH / 65 - 85 °C
3.1: HBF4; aq. NaNO2 / 1 h / 0 °C
3.2: 72 percent / 70 - 85 °C
4.1: 63 percent / 2 N aq. KOH / 24 h
View Scheme
参考文献
Brown, LaVerne L.; Kulkarni, Santosh; Pavlova, Olga A.; Koren, Andrei O.; Mukhin, Alexey G.; Newman, Amy H.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2841 - 2849
