α-(三甲基硅氧基)苯乙腈合成路线 （共 67 条）
反应条件
1: hydrogen cyanide; trimethylsilyl cyanide With 1-methyl-1H-imidazole; titanium(IV) isopropylate in dichloromethane T=-40°C; Inert atmosphere; 2: benzaldehyde in dichloromethane T=-40°C; 48 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 14, # 7 p. 2223 - 2231
反应条件
3C12H10N2*Co(2+)*2H2O*Ni(2+)*V4O12(4-) T=50°C; 16 h;
参考文献
Inorganic Chemistry, , vol. 52, # 5 p. 2615 - 2626
反应条件
1: CF3CO2H / 48 h / 20 °C 2: Et3N, TMSOTf / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 10 p. 1653 - 1656
反应条件
n-octadecyl-modified HMON@h-SiO2 with MnO2 functionalized silica in dichloromethane T=20°C; Inert atmosphere;
参考文献
Journal of Materials Chemistry, , vol. 20, # 47 p. 10615 - 10621
反应条件
in acetonitrile T=25°C; 2 h;
参考文献
Journal of Chemical Research - Part S, , # 11 p. 498 - 499
反应条件
lithium diisopropyl amide 1.1) Et2O, -78 deg C to room temp., 1.2) 40 min, reflux, 2.) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 46, # 8 p. 2999 - 3006
反应条件
1: diethyl ether / 4 h / Reflux 2: amidosulfonyl chloride / N,N-dimethyl acetamide / 1 h / 20 °C 3: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux 4: formic acid; (R,R)-RhCl(TsDPEN)Cp*; triethylamine / ethyl acetate / 0.25 h / 20 °C 5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok
Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5454 - 5460
反应条件
1: diethyl ether / 4 h / Reflux 2: amidosulfonyl chloride / N,N-dimethyl acetamide / 1 h / 20 °C 3: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux 4: formic acid; Rh-(S,S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; triethylamine / ethyl acetate / 0.25 h / 20 °C 5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C View Scheme
参考文献
Lee, Hyeon-Kyu; Kang, Soyeong; Choi, Eun Bok
Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5454 - 5460
反应条件
1.1: diethyl ether / 4 h / Reflux 2.1: amidosulfonyl chloride / N,N-dimethyl acetamide / 1 h / 20 °C 3.1: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux 4.1: formic acid; (R,R)-RhCl(TsDPEN)Cp*; triethylamine / ethyl acetate / 0.25 h / 20 °C 5.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.17 h / 20 °C 6.1: cesium fluoride / N,N-dimethyl-formamide / 12 h / 60 °C 6.2: 1 h / 20 °C 7.1: potassium cyanide / methanol / 4 h / 65 °C 8.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 12 p. 5454 - 5460
反应条件
sodium tetrahydroborate 1.) 2 h, 2.) MeOH, 4 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 12 p. 2933 - 2944
