α-(三甲基硅氧基)苯乙腈合成路线 （共 67 条）
反应条件
N-bromosuccinmide in pentane T=23°C; 20 h; Irradiationindirect daylight irradiation;
参考文献
Haerle, Helmut; Jochims, Johannes C.
Chemische Berichte, 1986 , vol. 119, # 4 p. 1400 - 1412
反应条件
lithium diisopropyl amide 1) -78 deg C, THF, 2) in 6 h to 0 deg C; Multistep reaction. Title compound not separated from byproducts;
参考文献
Huenig, Siegfried; Marschner, Claus
Chemische Berichte, 1990 , vol. 123, # 1 p. 107 - 114
反应条件
1: 1.) magnesium / 1.) ether, 2.) ether, CH2Cl2, 2 h 2: thionyl chloride / dimethylformamide / 3 h 3: diethyl ether View Scheme
参考文献
Bergmark, William R.; Dewan, Charlotte; Whitten, David G.
Journal of the American Chemical Society, 1992 , vol. 114, # 23 p. 8810 - 8812
反应条件
diethylamino-sulfur trifluoride in dichloromethane T=5 - 20°C; 0.5 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 25, # 46 p. 5227 - 5230
反应条件
sodium tetrahydroborate 1.) ether, RT, 1 h, 2.) EtOH, -76 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.
Australian Journal of Chemistry, 1990 , vol. 43, # 12 p. 2045 - 2062
反应条件
hydrogenchloride Ambient temperature; Title compound not separated from byproducts;
参考文献
Blocka, Ewelina; Bosiak, Mariusz J.; Welniak, Miroslaw; Ludwiczak, Agnieszka; Wojtczak, Andrzej
Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 554 - 562
反应条件
lithium diisopropyl amide 1) -78 deg C, THF, 2) in 6 h to 0 deg C; Multistep reaction. Title compound not separated from byproducts;
参考文献
Huenig, Siegfried; Marschner, Claus
Chemische Berichte, 1990 , vol. 123, # 1 p. 107 - 114
反应条件
di-tert-butyl peroxide in chlorobenzene 20 h; Heating;
参考文献
Haerle, Helmut; Jochims, Johannes C.
Chemische Berichte, 1986 , vol. 119, # 4 p. 1400 - 1412
反应条件
(i) LDA, THF, Et2O, (ii) /BRN= 635754/, (iii) (hydrolysis); Multistep reaction;
参考文献
Deuchert,K. et al.
Chemische Berichte, 1979 , vol. 112, p. 2045 - 2061
反应条件
1: HCl (gas) 2: Ph3P, CBr4 / CH2Cl2 / 0 - 20 °C 3: Cs2CO3 / dimethylformamide 4: Ph3P, CBr4 / CH2Cl2 5: Cs2CO3 / dimethylformamide 6: 1 N aq. NaOH / methanol View Scheme
参考文献
Dhanoa; Bagley; Chang; Lotti; Chen; Kivlighn; Zingaro; Siegl; Chakravarty; Patchett; Greenlee
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3738 - 3742
