α-(三甲基硅氧基)苯乙腈合成路线 （共 67 条）
反应条件
hydrogenchloride
1.) diethyl ether, r.t., 2.) water, reflux; Multistep reaction;
参考文献
Corrie, John E. T.; Trentham, David R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2409 - 2418
反应条件
1: 1) LDA / 2) -78 deg C, 2 h
2: 99 percent / CsF / acetonitrile / 2.5 h / Ambient temperature
View Scheme
参考文献
Huenig, Siegfried; Marschner, Claus
Chemische Berichte, 1990 , vol. 123, # 1 p. 107 - 114
反应条件
hydrogenchloride
T=5°C; 16 h;
参考文献
Schnur; Morville
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 770 - 778
反应条件
1: LDA / diethyl ether / -78 °C
2: diethyl ether / -78 degC -> 0 degC
3: 2 N HCl
View Scheme
参考文献
Huenig, Siegfried; Wehner, Gregor
Chemische Berichte, 1980 , vol. 113, # 1 p. 302 - 323
反应条件
1: 2-phenyl-2-(trimethylsilyloxy)ethanenitrile With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: 5-methyl-2-furancarboxaldehyde in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
参考文献
Hashmi, A. Stephen K.; Buehrle, Miriam; Woelfle, Michael; Rudolph, Matthias; Wieteck, Marcel; Rominger, Frank; Frey, Wolfgang
Chemistry - A European Journal, 2010 , vol. 16, # 32 p. 9846 - 9854
反应条件
sulfuric acid; iodine; copper; zinc
1.) THF; 2.) room temperature; Yield given. Multistep reaction;
参考文献
Krepski, Larry R.; Lynch, Laurie E.; Heilmann, Steven M.; Rasmussem, Jerald K.
Tetrahedron Letters, 1985 , vol. 26, # 8 p. 981 - 984
反应条件
1: LDA / diethyl ether / -78 °C
2: diethyl ether / -78 degC -> 0 degC
3: 2 N HCl
View Scheme
参考文献
Huenig, Siegfried; Wehner, Gregor
Chemische Berichte, 1980 , vol. 113, # 1 p. 302 - 323
