(3S,5R,6E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-3,5-二羟基-6-庚烯酸合成路线 (共 6 条)
反应条件
1.1: DMSO; P2O5; Et3N
2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O
3.1: DIBAH
4.1: NaH; n-BuLi
5.1: NaBH4; Et2BOMe / -78 °C
6.1: aq. NaOH
6.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: NaOH; (n-octyl)3MeNCl / toluene; H2O
2.1: DIBAH
3.1: NaH; n-BuLi
4.1: NaBH4; Et2BOMe / -78 °C
5.1: aq. NaOH
5.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
sodium hydroxide in methanol
12 h; Ambient temperature;
参考文献
Hiyama; Reddy; Minami; Hanamoto
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 1 p. 350 - 363
反应条件
1.1: NaH; n-BuLi
2.1: NaBH4; Et2BOMe / -78 °C
3.1: aq. NaOH
3.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: DIBAH
2.1: NaH; n-BuLi
3.1: NaBH4; Et2BOMe / -78 °C
4.1: aq. NaOH
4.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: NaBH4; Et2BOMe / -78 °C
2.1: aq. NaOH
2.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982