3-羟基-2-氨基甲酸苯丙酯合成路线 （共 8 条）
反应条件
1: in tetrahydrofuran 2: With (NH4)2CO3 in tetrahydrofuran 38 - 72 h; Molecular sieve;
参考文献
Mortko, Henry; He, Weixuan; Andersen, Marc W.; Dotse, Anthony K.; Li, Jie
Patent: US2006/241298 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
1: in tetrahydrofuran T=20°C; 1 h; 2: With ammonia in tetrahydrofuran T=-48°C; 3 h;
参考文献
Thompson, Charles D.; Gulden, Pamela H.; Macdonald, Timothy L.
Chemical Research in Toxicology, 1997 , vol. 10, # 4 p. 457 - 462
反应条件
trichloromethyl silane; sodium iodide in acetonitrile 24 h; Ambient temperature;
参考文献
Choi; Kucharczyk; Sofia
Tetrahedron, 1986 , vol. 42, # 23 p. 6399 - 6404
反应条件
1: in tetrahydrofuran 2 h; Inert atmosphere; 2: With ammonia in tetrahydrofuran T=-78°C; 2 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran 1 h;
参考文献
Miller, Thomas A.; Dieckhaus, Christine M.; Macdonald, Timothy L.
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 611 - 612
反应条件
1: 1.) sodium hydride / 1.) DMSO, RT, 5 h, 2.) RT, overnight 2: tetrahydrofuran / 2 h / Ambient temperature 3: ammonia / toluene / 0.5 h / 0 °C 4: 96 percent / trichloromethylsilane, sodium iodide / acetonitrile / 24 h / Ambient temperature View Scheme
参考文献
Choi; Kucharczyk; Sofia
Tetrahedron, 1986 , vol. 42, # 23 p. 6399 - 6404
反应条件
1: in tetrahydrofuran T=20°C; 1 h; 2: With ammonia in tetrahydrofuran T=-48°C; 3 h;
参考文献
Thompson, Charles D.; Gulden, Pamela H.; Macdonald, Timothy L.
Chemical Research in Toxicology, 1997 , vol. 10, # 4 p. 457 - 462
反应条件
1: With Dess-Martin periodane in dichloromethane
2 h;
2: With triethylamine in dichloromethane
1 h;
参考文献
Dieckhaus, Christine M.; Roller, Shane G.; Santos, Webster L.; Sofia, R. Duane; Macdonald, Timothy L.
Chemical Research in Toxicology, 2001 , vol. 14, # 5 p. 511 - 516
反应条件
Dess-Martin periodane in dichloromethane
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Dieckhaus; Santos; Sofia; Macdonald
Chemical Research in Toxicology, 2001 , vol. 14, # 8 p. 958 - 964
