1-溴-4-(甲氧基甲氧基)苯合成路线 （共 19 条）
反应条件
1.1: Mg; I2 / tetrahydrofuran / Heating 1.2: n-Bu3SnCl / tetrahydrofuran / 4 h / 20 °C 1.3: PdCl2(PPh3)4 / CHCl3 / 11 h / Heating 2.1: 250 mg / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5117 - 5133
反应条件
1.1: Mg; I2 / tetrahydrofuran / Heating 1.2: n-Bu3SnCl / tetrahydrofuran / 4 h / 20 °C 1.3: PdCl2(PPh3)4 / CHCl3 / 11 h / Heating 2.1: 271 mg / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5117 - 5133
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, reflux, 3 h 2: 3N aq. HCl / tetrahydrofuran / 3 h / Heating 3: 77 percent / AlCl3, DDQ / nitromethane / 1.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 8 p. 1377 - 1380
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 5 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water T=0°C; 0.5 h;
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1.1: Mg; I2 / tetrahydrofuran / Heating
1.2: n-Bu3SnCl / tetrahydrofuran / 4 h / 20 °C
1.3: PdCl2(PPh3)4 / CHCl3 / 11 h / Heating
2.1: 2.1 g / aq. HCl / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5117 - 5133
反应条件
magnesium
1.) THF, 2.) THF, reflux, 3 h; Multistep reaction;
参考文献
Gu, Wenxin; She, Xuegong; Pan, Xinfu; Yang, Teng-Kuei
Tetrahedron Asymmetry, 1998 , vol. 9, # 8 p. 1377 - 1380
反应条件
1: 82 percent / Cs2CO3 / Pd(PPh3)4 / tetrahydrofuran / Heating
2: 81 percent / aq. HCl / 16 h / 20 °C
View Scheme
参考文献
Diemer, Vincent; Chaumeil, Helene; Defoin, Albert; Jacques, Patrice; Carre, Christiane
Tetrahedron Letters, 2005 , vol. 46, # 28 p. 4737 - 4740
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate
12 h; Inert atmosphereReflux;
参考文献
Kikuchi, Haruhisa; Matsuo, Yusuke; Katou, Yasuhiro; Kubohara, Yuzuru; Oshima, Yoshiteru
Tetrahedron, 2012 , vol. 68, # 43 p. 8884 - 8889
反应条件
1.1: Mg; I2 / tetrahydrofuran / Heating
1.2: n-Bu3SnCl / tetrahydrofuran / 4 h / 20 °C
1.3: 662 mg / PdCl2(PPh3)2 / CHCl3 / 11 h / Heating
2.1: 218 mg / aq. HCl / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5117 - 5133
