1-甲氧基甲氧基-4-甲基苯; 4-(甲氧基甲氧基)甲苯合成路线 （共 12 条）
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) ether, hexane, -20 deg C, 1 h, 2.) 1 h; Yield given. Multistep reaction;
参考文献
Harvey; Cortez; Ananthanarayan; Schmolka
Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 3936 - 3943
反应条件
1.1: C6H5LiO2S / toluene; tetrahydrofuran; hexane / 2 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique
1.2: 18 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique
2.1: water; toluene; tetrahydrofuran; hexane / |Inert atmosphere; |Schlenk technique; |Reflux
3.1: hydrogenchloride; water / dichloromethane; ethanol; methanol / 12 h / 20 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Rihn, Sandra; Retailleau, Pascal; De Nicola, Antoinette; Ulrich, Gilles; Ziessel, Raymond
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 8851 - 8863
