1: 70 percent / NaH / tetrahydrofuran / a.) 0 deg C, 2 h, b.) room temperature, 3 h, c.) 40 deg C, 3 h 2: 17.20 g / LiAlH4 / diethyl ether / a.) 0 deg C, 30 min, b.) room temperature, 5.5 h 3: 72 percent / pyridine / 4 h / 0 °C 4: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 5: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme

1: 17.20 g / LiAlH4 / diethyl ether / a.) 0 deg C, 30 min, b.) room temperature, 5.5 h 2: 72 percent / pyridine / 4 h / 0 °C 3: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 4: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme

1: 72 percent / pyridine / 4 h / 0 °C 2: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 3: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme

1: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 2: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme

in water; isopropyl alcohol pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4);

1,4-diaza-bicyclo[2.2.2]octane; sodium tetrahydroborate; sodium sulfate 1.) THF, RT, 48 h, 2.) EtOH, RT, 48 h; Yield given. Multistep reaction;