2-氯-6-甲基吡啶-4-羧酸合成路线 （共 24 条）
反应条件
trichlorophosphate 18 h; Inert atmosphereReflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4629 - 4635
参考文献
Journal of the American Chemical Society, , vol. 81, p. 704,707
反应条件
1: POCl3; PCl5 2: ethanolic KOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 81, p. 704,707
反应条件
potassium permanganate; water
参考文献
Journal of the Chemical Society, , vol. 71, p. 653,655
反应条件
1: hydrogenchloride; water / 24 h / 115 °C / Inert atmosphere 2: trichlorophosphate / 18 h / Inert atmosphere; Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4629 - 4635
反应条件
sulfuric acid T=0 - 80°C;
参考文献
Exelixis, Inc.
Patent: US2010/249071 A1, 2010 ;
Location in patent: Page/Page column 63-64 ;
反应条件
in ethanol; dichloromethane
参考文献
Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A
反应条件
sulfuric acid in ethanol 2 h; Heating / reflux;
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 43 ;
US 6362336 B1
反应条件
in methanol; dichloromethane
参考文献
Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A
反应条件
hydrogenchloride 6 h; Heating;
参考文献
Havas, Fabien; Danel, Mathieu; Galaup, Chantal; Tisnes, Pierre; Picard, Claude
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 999 - 1002
